Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

Abstract

A review. The applications of flow chem. in a drug discovery environment are discussed within. The development of integrated synthesis-bioassay platforms is discussed in the context of enabling medicinal chem. programs, as is the use of flow chem. to facilitate intermediate scale-up in a lead optimization setting. Emerging chem. technologies are also discussed, highlighting the use of high temperatures, hazardous gases, and photochem. in flow to support medicinal chem. efforts.