NMR data from large studies combining multiple cohorts is becoming common in large-scale metabolomics. The data size and combination of cohorts with diverse properties leads to special problems for data processing and analysis. These include alignment, normalization, detection and removal of outliers, presence of strong correlations, and the identification of unknowns. Nonetheless, these challenges can be addressed with suitable algorithms and techniques, leading to enhanced data sets ripe for further data mining.
CITATION STYLE
Ebbels, T. M. D., Karaman, I., & Graça, G. (2019). Processing and Analysis of Untargeted Multicohort NMR Data. In Methods in Molecular Biology (Vol. 2037, pp. 453–470). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9690-2_25
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