Rare variants distributed across large genomic regions make a substantial contribution to the genetic basis of complex diseases, according to a simulated genome-wide association (GWA) study that is backed by real disease-mapping data.\rGWA studies are based on the assumption that complex diseases are caused by many common variants of small effect, and the signals observed in GWA studies are assumed to correspond to common variants.
CITATION STYLE
Casci, T. (2010). Rare treasures. Nature Reviews Genetics, 11(3), 170–170. https://doi.org/10.1038/nrg2754
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