Phenopyrrozin, a New Radical Scavenger Produced by Penicillium sp. FO-2047

Abstract

A new radical scavenger, named phenopyrrozin, was isolated from the culture broth of Penicillium sp. FO-2047. Phenopyrrozin was purified from whole broth by solvent extraction, silica gel chromatography, and HPLC. The structure of phenopyrrozin was elucidated as 5,6,7,7a-tetrahydro-2-hydroxy-l-phenyl-3H-pyrrolizin-3-one. The IC50 of phenopyrrozin against lipid peroxidation induced by Cr2K207 was 73 μg/ml. Phenopyrrozin also reduced chromosomal aberrations induced by paraquat. © 1995, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.