α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors. This journal is © the Partner Organisations 2014.
CITATION STYLE
Barnard, A., Long, K., Yeo, D. J., Miles, J. A., Azzarito, V., Burslem, G. M., … Wilson, A. J. (2014). Orthogonal functionalisation of α-helix mimetics. Organic and Biomolecular Chemistry, 12(35), 6794–6799. https://doi.org/10.1039/c4ob00915k
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