Orthogonal functionalisation of α-helix mimetics

24Citations
Citations of this article
57Readers
Mendeley users who have this article in their library.

Abstract

α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors. This journal is © the Partner Organisations 2014.

Cite

CITATION STYLE

APA

Barnard, A., Long, K., Yeo, D. J., Miles, J. A., Azzarito, V., Burslem, G. M., … Wilson, A. J. (2014). Orthogonal functionalisation of α-helix mimetics. Organic and Biomolecular Chemistry, 12(35), 6794–6799. https://doi.org/10.1039/c4ob00915k

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free