The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.
CITATION STYLE
de Leeuw, A. J. M., Oude Luttikhuis, M. A. M., Wellen, A. C., Müller, C., & Calkhoven, C. F. (2021, July 1). Obesity and its impact on COVID-19. Journal of Molecular Medicine. Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s00109-021-02072-4
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