Evaluation of an extended period of use for preserved eye drops in hospital practice

Abstract

Aim - To evaluate and compare the microbial contamination arising from 1 and 2 weeks' use of eye drops by hospital inpatients and hence determine the validity of apportioning a 2 week in use expiry date for these preparations. Methods - Eye drop residues were collected from inpatients of Worthing, Southlands, and Brighton General hospitals after 7 days' use (341 samples) and also after 14 days' use (295 samples). The contents of the containers were examined for the presence of contaminating bacteria and fungi. Results - The incidence of microbial contamination was shown to be not significantly different (p > 0.1 χ2 test) between the 7 and 14 day samples. In addition, the contaminating micro-organisms were of a broadly similar pattern between the two sample groups and were mostly those normally associated with the skin. Less frequent contaminants were organisms of environmental origin. None of the micro-organisms isolated were considered to be of clinical significance and the mean number of cells found per sample was very low. Conclusions - The evidence therefore suggests that increasing the period of use for eye drops in hospitals from 7 to 14 days would not present a clinically significant threat to patients' health and yet may lead to annual savings to the NHS of £0.5 million.