Growth hormone insensitivity syndromes

Abstract

Pathogenesis 609 Clinical diagnosis of growth hormone insensitivity 609 Biochemical and molecular investigations 610 Growth hormone insensitivity due to STAT5b mutation 611, Treatment 611 Conclusions 612 Key learning points 612 References 612, The term growth hormone insensitivity syndrome (GHIS) describes a group of inherited disorders characterized by a reduction in the biological effects of GH in the presence of normal or elevated serum GH concentrations.