Network Changes after Epilepsy Surgery: It's Time to Reconnect

Abstract

Network-Targeted Approach and Postoperative Resting-State Functional Magnetic Resonance Imaging Are Associated With Seizure Outcome Boerwinkle VL, Cediel EG, Mirea L, et al. Ann Neurol. 2019;86(3):344-356. Objective: Postoperative resting-state functional magnetic resonance imaging (MRI) in children with intractable epilepsy has not been quantified in relation to seizure outcome. Therefore, its value as a biomarker for epileptogenic pathology is not well understood. Methods: In a sample of children with intractable epilepsy who underwent prospective resting-state seizure onset zone (SOZ)-targeted epilepsy surgery, postoperative resting-state functional MRI (rs-fMRI) was performed 6 to 12 months later. Graded normalization of the postoperative resting-state SOZ was compared to seizure outcomes, patient, surgery, and anatomical MRI characteristics. Results: A total of 64 cases were evaluated. Network-targeted surgery, followed by postoperative rs-fMRI normalization was significantly (P