2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance

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Abstract

A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4- dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH). © 2010 by the authors; licensee MDPI, Basel, Switzerland.

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Shi, J., Zhang, X., & Jiang, H. (2010). 2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a novel NQO1 inducing agent from Echinops grijsii Hance. Molecules, 15(8), 5273–5281. https://doi.org/10.3390/molecules15085273

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