An Abnormality of Oestrogen Feedback in Amenorrhoea-Galactorrhoea

Abstract

Fourteen patients with amenorrhoea and hyperprolactinaemia but no evidence of pituitary tumours were each given an intramuscular injection of 1 mg oestradiol benzoate. Thirteen patients failed to release luteinizing hormone in response to the oestrogen. This hypothalamic abnormality may help to explain the menstrual disturbances in subjects with hyperprolactinaemia. © 1975, British Medical Journal Publishing Group. All rights reserved.