Genetic polymorphism in CYP1A1 affected susceptibility to acne vulgaris in Pekanbaru Indonesian Population, Desember 2013-Maret 2014

Abstract

Background: Susceptibility to acne vulgaris had seen by modulating devolution of encoding cytochrome P450 1A1 (CYP1A1) gene polymorphism which is involved in bioactivation and detoxification of drugs, chemical agents, and pollutants from the environment. Acne incidence is known different based on ethnic, so that, we did this study in Indonesian acne vulgaris patients. Aim: To characterize cytochrome P450 1A1 (CYP1A1) polymorphism in Indonesian acne vulgaris patients. Method: Multiplex polymerase chain reaction (PCR) dan PCR based restriction fragment length polymorphism (PCR-RFLP) were used to detect polymorphism changes of CYP1A1 by doing a case-control study of 35 acne patients dan 35 controls. All the examination samples were obtained from Pekanbaru, Riau Province, Indonesia. Result: The frequency of CYP1A1 heterozygous variant alleles was higher in case (odds ratio 2.21; 95% Confidence Interval 0.71-6.87). Conclusion: Polymorphism of CYP1A1 allele m1 gene increases susceptibility to acne vulgaris.