The kidney plays an important role in maintaining total body homeostasis and eliminating toxic xenobiotics and metabolites. Numerous drugs and their metabolites are ultimately eliminated in the urine. The reabsorption and secretion functions of the nephron are mediated by a variety of transporters located in the basolateral and luminal membranes of the tubular cells. In the past decade, many studies indicated that transporters play important roles in drug pharmacokinetics and demonstrated the impact of renal transporters on the disposition of drugs, drug-drug interactions, and nephrotoxicities. Here, we focus on several important renal transporters and their roles in drug elimination and disposition, drug-induced nephrotoxicities and potential clinical solutions.
CITATION STYLE
Yang, X., & Han, L. (2019). Roles of renal drug transporter in drug disposition and renal toxicity. In Advances in Experimental Medicine and Biology (Vol. 1141, pp. 341–360). Springer New York LLC. https://doi.org/10.1007/978-981-13-7647-4_7
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