Levofloxacin resistance in Haemophilus influenzae has increased significantly in Taiwan, from 2.0% in 2004 to 24.3% in 2010 (p<0.001). Clinical and molecular investigations of 182 levofloxacin-resistant isolates revealed that the increase was mainly the result of the spread of several clones in the elderly population in different regions.
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Kuo, S. C., Chen, P. C., Shiau, Y. R., Wang, H. Y., Lai, J. F., Huang, I. W., & Yang Lauderdale, T. L. (2014). Levofloxacin-resistant Haemophilus influenzae, Taiwan, 2004-2010. Emerging Infectious Diseases, 20(8), 1386–1390. https://doi.org/10.3201/eid2008.140341