Laboratory Evaluation of a New Antibiotic-Cephaloridine (Ceporin)

Abstract

Cephaloridine (Ceporin) is a new semisynthetic antibiotic derived from cephalosporin C. It has a broad spectrum of activity in vitro, and is active against both penicillin-sensitive and penicillin-resistant strains of Staph. aureus. It is bactericidal in action. It is highly effective in protecting experimentally infected mice against Staph. aureus, E. coli, Pr. mirabilis, and Salmonella spp. Good blood levels are attained in experimental animals after intramuscular injection. Intramuscular injection of 250 and 500 mg. doses into human volunteers gave good serum levels, high urinary levels, good urinary recovery, and complete freedom from undesirable side-effects. © 1964, British Medical Journal Publishing Group. All rights reserved.