Age-related macular degeneration (AMD) is the main cause of visual impairment and blindness in people aged over 65 years in developed countries. Vascular endothelial growth factor (VEGF) is a positive regulator of angiogenesis and its proven role in the pathological neovascularization in wet AMD has provided evidence for the use of anti-VEGF agents as potential therapies. In this study, we review the literature for the possible causes of failure after treatment with anti-VEGF agents and attempt to propose an algorithm of suggestive actions to increase the chances of successful management of such difficult cases. © 2013 Tranos et al, publisher and licensee Dove Medical Press Ltd.
CITATION STYLE
Tranos, P., Vacalis, A., Asteriadis, S., Koukoula, S., Vachtsevanos, A., Perganta, G., & Georgalas, I. (2013, June 17). Resistance to antivascular endothelial growth factor treatment in age-related macular degeneration. Drug Design, Development and Therapy. https://doi.org/10.2147/DDDT.S43470
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