Trehalose-6-phosphate: Connecting plant metabolism and development

Abstract

Beyond their metabolic roles, sugars can also act as messengers in signal transduction. Trehalose, a sugar found in many species of plants and animals, is a non-reducing disac-charide composed of two glucose moieties. Its synthesis in plants is a two-step process, involving the production oftrehalose-6-phosphate (T6P) catalyzed by trehalose-6-phosphate synthase (TPS) and its consecutive dephosphorylation to trehalose, catalyzed by trehalose-6-phosphate phosphatase (TPP). T6P has recently emerged as an important signaling metabolite, regulating carbon assimilation and sugar status in plants. In addition, T6P has also been demonstrated to play an essential role in plant development.This review recapitulates the recent advances we have made in understanding the role ofT6P in coordinating diverse metabolic and developmental processes. © 2011 Ponnu, Wahl and Schmid.