TMPRSS2-Inhibitors Play a role in Cell Entry Mechanism of COVID-19: An Insight into Camostat and Nafamostat

Abstract

The enzymes trypsin, furin and other proprotein-convertasen, cathepsin, transmembrane proteases (TMPRSS) and elastases play a role by the cell entry of Coronaviren (Coronaviridae). The proteases TMPRSS2 and TMPRSS11a, which exist in the respiratory tract richly and become experiment on cell surfaces, promote the entry of SARS-CoV-1-virus. For the TMPRSS-protease TMPRSS11d - also as protease similar to trypsin has confessed of the human respiratory tract - a proteolytic activation of the spike protein was proved by SARS-CoV.