We propose a method for the segmentation of Multiple Sclerosis lesions. The method is based on probability maps derived from a K-Nearest Neighbours classification. These are used as a non parametric likelihood in a Bayesian formulation with a prior that assumes connectivity of neighbouring voxels. The formulation is solved using the method of Iterated Conditional Modes (ICM). The parameters of the method are found through leave-one-out cross validation on training data after which it is evaluated on previously unseen test data. The multi modal features investigated are 3 structural MRI modalities, the diffusion MRI measures of Fractional Anisotropy (FA), Mean Diffusivity (MD) and several spatial features. Results show a benefit from the inclusion of diffusion primarily to the most difficult cases. Results shows that combining probabilistic K-Nearest Neighbour with a Markov Random Field formulation leads to a slight improvement of segmentations. © 2012 Springer-Verlag.
CITATION STYLE
Lyksborg, M., Larsen, R., Sørensen, P. S., Blinkenberg, M., Garde, E., Siebner, H. R., & Dyrby, T. B. (2012). Segmenting multiple sclerosis lesions using a spatially constrained K-nearest neighbour approach. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 7325 LNCS, pp. 156–163). https://doi.org/10.1007/978-3-642-31298-4_19
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