Composite Nano-fiber Mats Consisting of Biphasic Calcium Phosphate Loaded Polyvinyl Alcohol—Gelatin for Bone Tissue Engineering

Abstract

Electrospun blends of biphasic calcium phosphate (BCP) loaded polyvinyl alcohol (PVA)-gelatin (GE) were created with the aim of fabricating biodegradable scaffolds for bone tissue engineering. The process parameters including the electrical field and tip-to-collector distance (TCD) were investigated. The morphology of these hybrid scaffolds were characterized by scanning electron microscope (SEM). X-ray diffraction (XRD) was used to determine the crystallinity of the membrane. Adhesion of osteoblastic cells (MG-63) onto the BCP loaded PVA/GE composite nano-fiber mat was performed to assess potential of the product as a bone scaffold. This result suggests that the BCP loaded PVA/GE composite nano-fiber mat has a high potential for use in the field of bone regeneration and tissue engineering.