Many treatments in SSc were thought to be effective until subjected to a well-designed randomized trial. Relying on case reports may be misleading due to publication or reporting bias, selection bias, and lack of a control group. Furthermore, treatment that is not blinded is prone to an unconscious bias to a perception of response by both the investigator and patients.
CITATION STYLE
Kafaja, S., Furst, D. E., & Pope, J. E. (2012). Issues in clinical trial design. In Scleroderma: From Pathogenesis to Comprehensive Management (pp. 651–660). Springer US. https://doi.org/10.1007/978-1-4419-5774-0_54
Mendeley helps you to discover research relevant for your work.