Estudo de associação de casos-controle entre transtorno obsessivo-compulsivo (TOC) e polimorfismo MCP-1 -2518G/A em uma coorte chinesa

Abstract

Objective: To investigate the association between Obsessive-Compulsive Disorder (OCD) and a functional polymorphism of MCP-1 in the Chinese Han population. Method: We genotyped and performed a case-control association analysis of the MCP-1 -2518G/A polymorphism in 200 OCD patients and 294 healthy control subjects. Results: There was no significant difference in MCP-1 -2518G/A genotypic and allelic frequencies between OCD cases and controls (x2 = 1.123, df = 2, P = 0.57 by genotype; x2 = 0.802, df = 1, P = 0.37 by allele). Conclusions: Our results indicated that MCP-1 -2518G/A may not play a major role in the genetic predisposition of the Chinese Han population to OCD. However, further studies using a larger number of subjects are required to obtain a clear conclusion. © 2012 Elsevier Editora Ltda. All rights reserved.