Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation

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Abstract

We found that N-nitrosoaminoanisole derivatives tethered to dyes work as photocontrollable nitrosonium cation releasers and are converted to potent nitric oxide releasers in the presence of sodium ascorbate. The N-nitrosoaminoanisole derivative 2 worked as a more potent photovasodilating reagent ex vivo than previously reported nitric oxide releasers.

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APA

Ieda, N., Yoshikawa, Y., Tomita, N., Ohkubo, K., Hotta, Y., Kawaguchi, M., … Nakagawa, H. (2022). Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation. Chemical Communications, 58(60), 8420–8423. https://doi.org/10.1039/d2cc03193k

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