Rationale: Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. Methods: In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. © 2014 Elsevier Inc.
CITATION STYLE
Junge, K. M., Hörnig, F., Herberth, G., Röder, S., Kohajda, T., Rolle-Kampczyk, U., … Lehmann, I. (2014). The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy. Clinical Immunology, 152(1–2), 68–76. https://doi.org/10.1016/j.clim.2014.02.013
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