West Nile virus is a zoonotic agent causing life-threatening encephalitis in a proportion of infected patients. Older age, immunosuppression, and mutations in specific host genes (e.g., CCR5 delta-32 mutation) predispose to neuroinvasive infection. We report on two cases of severe West Nile encephalitis in recently-treated, different-aged, chronic lymphocytic leukemia patients. Both patients developed high-grade fever associated with severe neurological impairment. The younger one harboured germ-line CCR5 delta-32 mutation, which might have played a role in the pathogenesis of its neuroinvasive manifestations.
CITATION STYLE
Ferrarini, I., Rigo, A., Gandini, A., & Vinante, F. (2019). West Nile virus encephalitis in haematological setting: Report of two cases and a brief review of the literature. Mediterranean Journal of Hematology and Infectious Diseases, 11(1). https://doi.org/10.4084/MJHID.2019.033
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