Abstract
dos Santos et al. describe that trained immunity induced by β-glucan confers protection against L. braziliensis infections. Infection control is associated with IL-32 and IL-1 induction. Genetic variation in the IL-32 gene enhances induction of trained immunity leading to proinflammatory gene transcription in bone marrow hematopoietic stem and progenitor cells.
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dos Santos, J. C., Barroso de Figueiredo, A. M., Teodoro Silva, M. V., Cirovic, B., de Bree, L. C. J., Damen, M. S. M. A., … Joosten, L. A. B. (2019). β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32. Cell Reports, 28(10), 2659-2672.e6. https://doi.org/10.1016/j.celrep.2019.08.004
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