Abstract
We describe the activities of RX-P763, RX-P766, RX-P770, RX-P792, RX-P793, and RX-P808 against strains of resistant Pseudomonas aeruginosa. These compounds target the large subunit of the bacterial ribosome and have broad-spectrum activities against multidrug-resistant pathogens. All compounds demonstrated in vitro activity against P. aeruginosa, with MIC 90 values of 4 to 8 μg/ml (range, 0.5 to 64). These novel compounds had narrow MIC distributions and maintained activity despite resistance phenotypes to other commonly utilized agents. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Cite
CITATION STYLE
Housman, S. T., Sutherland, C., & Nicolau, D. P. (2012). In vitro evaluation of novel compounds against selected resistant Pseudomonas aeruginosa isolates. Antimicrobial Agents and Chemotherapy, 56(3), 1646–1649. https://doi.org/10.1128/AAC.05944-11
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
