Gadolinium-mesoporous silica as a potential magnetic resonance imaging contrast agent

Abstract

Gadolinium-mesoporous silica (Gd-MS) has been used widely as an alternative for synthesizing gadolinium-based Magnetic Resonance Imaging (MRI) contrast agents. In this study, Gd-MS was prepared by using the sol-gel method. Transmission Electron Microscopy (TEM) results gave an average pore size value of 38.184 nm, while the surface value of gadolinium mesoporous silica which is high at 580,666 nm. We describe the synthesis, characterization, and stability test of a novel type of magnetic nanoparticles based on Gd-Si oxide. The particles are nanosized and can enter cell easily. This is a completely novel biomedical application of mesoporous silica materials.