Formation of bacterial lineages can have adaptive value either as a division of labor or as a bet-hedging strategy, and may facilitate bacterial adaptation to hostile and/or unpredictable environments. Lineage formation is often under epigenetic control, thus avoiding the burden of mutation. Epigenetic lineages can be formed whenever a cell-to-cell difference (e.g., generated by intrinsic noise) is propagated by a heritable feedback loop. In other cases, the basis of bacterial lineage formation is more complex and involves the formation of heritable DNA methylation patterns. In Salmonella enterica, a pathogen of humans and livestock, lineage formation plays roles in host colonization, bacteriophage resistance, motility, biofilm formation, and adaptive resistance to antibiotics.
CITATION STYLE
Cota, I., & Casadesús, J. (2016). Formation of bacterial lineages in salmonella enterica by epigenetic mechanisms. In Epigenetics and Human Health (pp. 1–17). Springer Verlag. https://doi.org/10.1007/978-3-319-27186-6_1
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