Very efficient and rapid catalyst-free one-pot three component synthesis of 2,5-dihydro-5-imino-2-methylfuran-3,4-dicarboxylate derivatives under ultrasound irradiation

Abstract

We report a fast, efficient, and facile route for the synthesis of 2,5-dihydro-5-imino-2-methylfuran-3,4- dicarboxylate derivatives from the isocyanide, dialkyl acetylenedicarboxylate and acetic anhydride under ultrasound-assisted conditions. Utilization of easy reaction conditions, very high to excellent yields, and short reaction times makes this manipulation potentially very useful.