Usefulness of standardized uptake values for distinguishing adrenal glands with pheochromocytoma from normal adrenal glands by use of 6- 18F-fluorodopamine PET

Abstract

6-18F-Fluorodopamine (18F-FDA) PET is a highly sensitive tool for the localization of pheochromocytoma (PHEO). The aim of this study was to establish cutoff values for pathologic and physiologic adrenal gland tracer uptake. Methods: 18F-FDA PET with CT coregistration was performed in 14 patients (10 men and 4 women; age [mean ± SD], 42.9 ± 13.3 y) with unilateral adrenal gland PHEO and in 13 control subjects (5 men and 8 women; age, 51.7612.5 y) without PHEO. Standardized uptake values (SUVs) were compared between adrenal glands with PHEO and normal left adrenal glands in control subjects. Results: 18F-FDA accumulation was observed in all adrenal glands with PHEO and in 6 of 13 control adrenal glands (P = 0.02). The SUV was higher in adrenal glands with PHEO (mean ± SD, 16.1 ± 6.1) than in 18F-FDA-positive control adrenal glands (7.7 ± 1.4) (P = 0.005). SUV cutoffs for distinguishing between adrenal glands with PHEO and normal adrenal glands were 7.3 (100% sensitivity) and 10.1 (100% specificity). Conclusion: The SUVs of adrenal foci on 18F-FDA PET facilitate the distinction between adrenal glands with PHEO and normal adrenal glands. Copyright © 2007 by the Society of Nuclear Medicine, Inc.