Biocatalyst aided total synthesis of natural products

Abstract

Biocatalytic reactions are recently attracting attention as they offer various advantage over chemocatalysts and classical organic synthesis. Aided by the development of engineering techniques, such as site-directed mutagenesis and directed evolution, biocatalysts are modified to realize sustainable organic synthesis of API and natural products. In this mini review, recent applications of biocatalytic reactions in total synthesis of natural products are presented.