Liver antioxidant enzyme activities increase after taurine in ovariectomized rats

Abstract

The present study was performed to know the effects of taurine on the lipid level of plasma and liver, lipid peroxidation and antioxidative enzyme activities of liver tissue in ovariectomized (OVX) rats fed cholesterol. Twenty-four female SD rats (200 ± 5 g) were grouped; sham and ovariectomy groups, which were each randomly subgrouped; fed control and control supplemented with taurine (20 g/kg diet). The serum total cholesterol, TG (triglyceride), LDL-cholesterol, athrogenic index, and HDL-cholesterol of taurine diet group were not statistically different. Also the levels of liver total cholesterol, triglyceride were not considerably different in different diets. The lipid peroxidation of malondialdehyde concentration was considerably lower in taurine-feeding group than control-feeding group in ovariectomy group. The superoxide dismutase activity in liver tissue was significantly higher in rats fed taurine than in rats fed control diet in OVX rats. GSH-Px (glutathione peroxidase) activity was statistically greater at the rats fed taurine diets compared to rats fed control diet in ovariectomy group. Activity of catalase was higher in taurine group than in control group in ovariectomy group, but it was not significantly different. In conclusion, taurine supplementation was beneficial on antioxidative enzyme activities of liver tissue in ovariectomized rats fed cholesterol.