New Metabolites with Nematicidal and Antimicrobial Activities from the Ascomycete Lachnum papyraceum (Karst.) Karst: VI. Structure Determination of Non-halogenated Metabolites Structurally Related to Mycorrhizin A

Abstract

The structure determination of four new biologically active non-halogenated metabolites isolated from submerged cultures of the ascomycete Lachnum papyraceum is described. The compounds are structurally related to the antibiotic mycorrhizin A: (l'Z)-Dechloromycorrhizin A (12), a stereoisomer of dechloromycorrhizin A (5) previously isolated from the same fungus, as well as papyracon A (13), papyracon B (14) and papyracon C (15) containing an exocyclic double bond. The amounts of the latter three increased significantly when CaBr2 was added to the culture medium. The structures were determined by spectroscopic methods. © 1995, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.