Detection of extended - Spectrum beta - Lactamases in Escherichia coli isolates and it’s correlation with vesicoureteral reflux nephropathy

Abstract

Background: Vesicourethral reflux is the reverse flow of urine from the bladder to the ureter and then to kidneys. 30% to 40% of children are infected with urinary tract infections disease, and recenthly, one of the most common urinary tract infections has become Extended - Spectrum Beta - Lactamases (ESBL) Escherichia coli isolates. Objectives: The aim of this was to investigate the correlation between extended Extended Spectrum Beta Lactamase Escherichia coli isolates and reflux nephropathy disease in children. Methods: This was a case - cotrol study conducted on 200 children with or without reflux nephropathy referred to the pediatric clinic. The researchers selected two groups of children; 100 children with reflux nephropathy and 100 healthy children. Urinary tract infection was tested by urine culture and antibiogram. Correlation of reflux nephropathy and ESBL Escherichia coli infection were analyzed by the SPSS program. Results: Infected children with Extended Spectrum Beta Lactamase E. coli infection compared with healthy children, were more influenced by reflux nephropathy. Overall, 53% of case and 9% of control group had infection of ESBL Escherichia coli. Conclusions: Reflux nephropathy can be controlled by prevention of these types of infections.