High-throughput single-cell technologies have recently emerged as essential tools in biomedical research with great potential for clinical pathology when studying liquid and solid biopsies. We provide an update on current single-cell methods in cerebrospinal fluid research and diagnostics, focusing on high-throughput cell-type specific proteomic and genomic technologies. Proteomic methods comprising flow cytometry and mass cytometry as well as genomic approaches including immune cell repertoire and single-cell transcriptomic studies are critically reviewed and future directions discussed.
CITATION STYLE
Lanz, T. V., Pröbstel, A. K., Mildenberger, I., Platten, M., & Schirmer, L. (2019). Single-cell high-throughput technologies in cerebrospinal fluid research and diagnostics. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2019.01302
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