Introduction: Maternal dietary consumption during pregnancy has been inconclusively associated with acute leukemia (AL) in infants, probably because epidemiological evidence has emerged mainly from the analysis of one-by-one nutrient, which is not a real-life scenario. Our objective was to evaluate the association between AL in Mexican children under 2 years of age and their mothers’ nutrients concomitant intake during pregnancy, as well as to explore whether there are differences between girls and boys. Methods: We conducted a study of 110 cases of AL and 252 hospital-based controls in the Mexico City Metropolitan area from 2010 to 2019. We obtained information on maternal intake of 32 nutrients by a food frequency questionnaire and used weighted quantile sum regression to identify nutrient concomitant intakes. Results: We found a concomitant intake of nutrients negatively associated with AL (OR 0.17; CI95% 0.03,0.88) only among girls; and we did not find a nutrient concomitant intake positively associated with AL. Discussion: This is the first study that suggests nutrients that have been individually associated with AL are not necessarily the same in the presence of other nutrients (concomitant intake); as well as that maternal diet might reduce AL risk only in girls.
CITATION STYLE
Mérida-Ortega, Á., Pérez-Saldivar, M. L., Espinoza-Hernández, L. E., Dorantes-Acosta, E. M., Torres-Nava, J. R., Solís-Labastida, K. A., … López-Carrillo, L. (2023). A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years. Frontiers in Oncology, 13. https://doi.org/10.3389/fonc.2023.1239147
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