Agranulocytosis induced by multidrug therapy in leprosy treatment: a case report

  • Silva I
  • Oliveira C
  • Guedes W
  • et al.
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Abstract

Multidrug therapy (WHO/MDT) in multibacillary leprosy consists of treatment with rifampicin, dapsone and clofazimine. However, adverse effects can cause the patient to abandon treatment. We report on a patient who presented agranulocytosis and hemolytic anemia associated with this treatment regime. We also examined the importance of laboratory exams for diagnosis and follow-up of the patient, and for early detection of adverse effects, with a view to improving adhesion to treatment and contributing to the eradication of Hansen's disease as a public health issue.

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Silva, I. M. B. da, Oliveira, C. A. P. de, Guedes, W. R. C. de A., Oliveira, B. B. de, Oliveira, D. A. P. de, & Guedes Filho, G. (2009). Agranulocytosis induced by multidrug therapy in leprosy treatment: a case report. Brazilian Journal of Infectious Diseases, 13(2). https://doi.org/10.1590/s1413-86702009000200018

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