Synthesis, Characterization, Antimicrobial Activity, Antifungal Activity and DNA Cleavage Studies of Transition Metal Complexes with Schiff Base Ligand

Abstract

Transition metal complexes of Cu(II), Co(II), Ni(II) and Zn(II) have been synthesized with the Schiff base ligand prepared by the condensation reaction between isooxazol-3-yl amine and salicylaldehyde. Elemental analysis of these complexes suggest that these metal ions forms complexes of type ML 2 (H 2 O) 2 stoichiometry for Cu(II), Co(II), Ni(II) and Zn(II). The ligand behaves as bidentate and forms coordinate bonds through O and N atoms. Magnetic susceptibility, IR, UV – Visible, Mass and ESR spectral studies suggest that Cu(II), Co(II), Ni(II) and Zn(II) complexes posses octahedral geometry. The complexes were tested for their antimicrobial activity against the bacterial strains Staphylococcus aureus and Bacillus subtilis. The Schiff base metal complexes evaluated for their antifungal activity against the fungi Aspergillus niger and Cladosporium oxysporum. The DNA cleavage studies of Schiff base complexes were studied by agarose gel electrophoresis method using Calf – Thymus DNA.