Patients with oligosecretory myeloma are often excluded from clinical trials because their disease is difficult to measure on standard tests. Measurement of free light chains is a method to evaluate disease in many of these patients.
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Larson, D., Kyle, R. A., & Rajkumar, S. V. (2012). Prevalence and Monitoring of Oligosecretory Myeloma. New England Journal of Medicine, 367(6), 580–581. https://doi.org/10.1056/nejmc1206740