FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy

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Abstract

van der Weijden et al. perform genomic, proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause.

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van der Weijden, V. A., Stötzel, M., Iyer, D. P., Fauler, B., Gralinska, E., Shahraz, M., … Bulut-Karslioglu, A. (2024). FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. Nature Cell Biology, 26(2), 181–193. https://doi.org/10.1038/s41556-023-01325-3

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