Stop! In the name of transforming growth factor-β: Keeping estrogen receptor-α-positive mammary epithelial cells from proliferating

Abstract

Recent genetic and cell biological studies illustrate the importance of active transforming growth factor-β signaling in preventing the proliferation of estrogen receptor-positive cells in the normal mammary gland, and suggest how the loss of this inhibition may be important in early breast cancer progression. © 2006 BioMed Central Ltd.