Acute generalized exanthematous pustulosis (AGEP) is a rare, severe, pustular reaction pattern, attributed mainly to drugs. Other triggers such as infections, spider bite, and contact sensitivity have been implicated. AGEP is characterized by typical morphology, unique histology, and a rapid clinical course. The AGEP validation score (EuroSCAR group criteria) is a useful tool for establishing the diagnosis. The immune pathogenesis involves drug-specific T-cells, neutrophils, and the release of cytokines/chemokines (i.e., IL-8/CXCL8). In view of the remarkable clinical and histological similarity between AGEP and pustular psoriasis, the genetic basis of AGEP should be further evaluated.
CITATION STYLE
Halevy, S. (2018). Acute Generalized Exanthematous Pustulosis. In Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions: Current and Future Trends (pp. 105–122). Springer Singapore. https://doi.org/10.1007/978-981-13-1489-6_8
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