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Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism

  • Sassa S
Springer Berlin Heidelberg, (1978), 333-371
DOI: 10.1007/978-3-642-66763-3_11
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Abstract

Lead has been shown to interfere with the biosynthesis of heme in a number of in vitro systems and in experimental animals as well as in human beings. Several steps of the heme biosynthetic chain are subject to the toxic effects of lead. ALA-dehydratase and ferrochelatase, in particular, are two enzymes which are strongly inhibited by lead, leading to decreased heme synthesis.

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Sassa, S. (1978). Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism. In Heme and Hemoproteins (pp. 333–371). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-66763-3_11

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