Endotoxic shock is a serious systemic inflammatory response to an external biological stressor. The responsiveness of NF-kappaB is built upon rapid protein modification and degradation involving the ubiquitin proteasome pathway. Using transgenic mice, we have obtained in vivo evidence that interference with this pathway can alleviate the symptoms of toxic shock. We posit that administration of proteasome inhibitors may enhance the survival of patients with septic shock.
CITATION STYLE
Brun, J., & Gray, D. A. (2009). Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients. Critical Care (London, England), 13(4), 311. https://doi.org/10.1186/cc7946
Mendeley helps you to discover research relevant for your work.