Cholesterol-lowering effect of black tea polyphenols, theaflavins, theasinensin a and thearubigins, in rats fed high fat diet

Abstract

Rats were fed a high fat diet containing 0.2% black tea polyphenols, theaflavins, theasinensin A or thearubigins for 4 weeks. The hepatic cholesterol concentration was significantly lower in rats fed the theaflavins, theasinensin A or thearubigins diet than in those fed the control diet without black tea polyphenols. Theasinensin A and thearubigins significantly accelerated fecal neutral and acidic steroid excretion, respectively. These results suggest that theasinensin A and thearubigins might induce the hepatic cholesterol-lowering activity through the promotion of fecal steroid excretion.