Steroidal alkaloids from the roots and rhizomes of Vertrum nigrum L.

Abstract

Two new steroidal alkaloids, neoverapatuline (1) and (1β,3α, 5β)-1,3-dihydroxyjervanin-12-en-11-one (2), together with the four known compounds, veratramine (3), rubijervine (4), veratrosine (5), and veratroylzygadenine (6), were isolated from the roots and rhizomes of Veratrum nigrum L. Their structures were established through combined analyses of physicochemical properties and spectroscopic evidence. All compounds 1-6 were tested for their cytotoxicities in vitro against the human glioma cell line SF188. © 2007 Verlag Helvetica Chimica Acta AG.