Analysis of the sialic acid-binding activity of transmissible gastroenteritis virus

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Abstract

Porcine transmissible gastroenteritis virus (TGEV) has been shown to agglutinate erythrocytes using α2,3-linked sialic acid on the cell surface as binding site. The hemagglutinating activity requires the pretreatment of virus with neuraminidase. We obtained evidence that TGEV recognizes not only N-acetylneuraminic acid but also N-glycoloylneuraminic acid, a sialic acid present on many porcine cells.

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Schultze, B., Enjuanes, L., & Herrler, G. (1995). Analysis of the sialic acid-binding activity of transmissible gastroenteritis virus. In Advances in Experimental Medicine and Biology (Vol. 380, pp. 367–370). Springer New York LLC. https://doi.org/10.1007/978-1-4615-1899-0_59

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