Abstract
A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-a production in lipopolysaccharide-stimulated THP-1 cells. The most active compound, 40g, inhibited TNF-a release with an IC50 value of 0.033 μM, which is equipotent to that of BIRB796 (IC50 = 0.032 μM). © 2014 by the authors; licensee MDPI, Basel, Switzerland.
Author supplied keywords
Cite
CITATION STYLE
Li, X., Zhou, X., Zhang, J., Wang, L., Long, L., Zheng, Z., … Zhong, W. (2014). Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-a agents that Target the p38 MAPK Pathway. Molecules, 19(2), 2004–2028. https://doi.org/10.3390/molecules19022004
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
