Dietary boron intake does not change the ischemic tolerance and preconditioning response in isoproterenol-induced myocardial injury in healthy rats

Abstract

Aim: Boron is important for many enzymes, most of which also have a role in the ischemic tolerance of the myocardium. We aimed to evaluate the influence of dietary boron intake on ischemic tolerance in a rat model. Materials and methods: Rats were divided into 3 groups according to the ischemia protocol: Sham (S) (n = 20 total), ischemia only (Isc-only) (n = 40 total), and remote ischemic preconditioning + ischemia (RIPC+Isc) (n = 40 total) groups. These 3 groups were further divided into 4 according to the amount of daily dietary boron (<1 mg/kg, 2 mg/kg, 13 mg/kg, and 100 mg/kg). After 4 weeks of this diet, the rats were operated on, and baseline hemodynamic data and postoperative blood serum were obtained. Results: Troponin I (Tn I) levels were lower in the RIPC+Isc group than in the Isc-only group (P < 0.01), whereas Tn I levels were not different among the dietary groups (P = 0.725). The Tn I levels were higher in the RIPC+Isc and in the Isc-only group than in the S group (P < 0.001 and P < 0.001, respectively). Conclusion: Boron in diets did not influence the extent of myocardial injury in the groups. Furthermore, dietary boron does not deteriorate the response of the most potent endogenous mechanism of the heart against ischemia. © TÜBİTAK.